Pfizer Inc Uses EDEM® to Guide Development of New Tablet Shapes
For several years, researchers at Pfizer have been applying EDEM simulation and analysis as a tool to examine and predict the effects of pharmaceutical production processes, such as tablet coating, on individual tablets at lab and full scale.
“EDEM simulation shows inter-tablet variability of film coating thickness by varying degrees of blue color on each tablet "
Results of recent Pfizer research has been published in a special Solid Dosage and Excipients issue of Pharmaceutical Technology magazine (April 1, 2011). The article, "Accelerating tablet shape selection: Pfizer and DEM Solutions' predictive computational model”, discusses a recently developed model that can help guide pharmaceutical manufacturers in the selection of tablet shape and operating parameters for a given equipment geometry to ensure film-coating uniformity.
In the article, Pfizer Senior Scientist, William R. Ketterhagen, and Associate Research Fellow Mary T. am Ende, located at Pfizer Worldwide Research & Development (Groton, Connecticut, USA), report that the deployment of EDEM modeling in Pfizer drug-product development has accelerated the decision-making process by predicting, before process scale-up, the performance of commercial tablet shapes at process scale.
Read more about Pfizer’s success with EDEM in the April 1, 2011 print version of Pharmaceutical Technology magazine or in the online version at PharmTech.com (page two of the Tablet Coating Innovations section).
Be sure to watch the EDEM video demo at the end of the article (also displayed on the LabTV channel of PharmTech Lab TV )
About Pfizer:
Pfizer, the world's largest research-based pharmaceutical company, strives to set the standard for quality, safety and value in the discovery, development and manufacturing of medicines for people and animals.